锌盐及其化验研究

介绍了锌盐对人体的作用，对锌盐的化验方法进行了研究，包括锌的定性分析和定量分析。锌的定量分析又包括：EDTA滴定法和萃取吸光光度法。     

原油饱和烃指纹的内标法分析

采用内标法建立了原油中正构烷烃、生物标志物(甾、萜烷类)的分析方法。确定了样品前处理方法和组分定性定量方法。讨论了柱层析分离能力。结果表明,所有饱和烃组分均流入第一部分流出液F1中,分离能力较为满意。对48种甾、萜烷类生物标志物组分以及姥鲛烷、植烷和正构烷烃等进行了定性确认,定性化合物数量多,信息量大,易于据此进行可靠的油指纹分析鉴别。32个正构烷烃组分相对标准差为1.2%～7.4%;45个生物标志物组分相对标准偏差为2.5%～9.2%。分析精密度较好,满足油指纹鉴别需要。正构烷烃回收率为73%～116%;生物标志物为84%～106%;回收率结果较为满意。正构烷烃方法检出限为7.0μg/g;生物标志物为0.65μg/g,满足原油样品分析要求。通过本方法对自不同和相同平台的原油样品进行饱和烃浓度分析,并采用浓度数据进行鉴别,结果与实际情况相符。     

中学生营养平衡米膳食最佳模式评价

根据中国营养学会推荐的热量标准,研制了中学生营养平衡米膳食最佳模式。按该模式,中学生每日应摄入的膳食品种及其数量如下:主食:营养平衡米,初中男生510~597g,女生468~510g;高中男生618~683g,女生532~575g;副食相同:青菜或水果500g或600g,鱼或肉100g或50g,蛋类40g,大豆制品30g,花生油12.5g,盐6g。调查结果表明,蛋白质、脂肪、碳水化合物,热量摄入量全部达标准要求。Q(蛋白质)∶Q(脂肪)∶Q(碳水化合物):高中男女生为16∶20∶64,初中男、女生分别为17∶20∶63。提示中学生营养平衡米膳食最佳模式使中学生达到营养平衡,建议推广食用。     

The interface of the Ising model and the Brownian sheet

We study the limit theorem related to the interface of the three-dimensional Ising model. Dobrushin proved that the interface does not fluctuate and becomes rigid for sufficiently large. We define the random fieldX ^L (t, s), 0t, s1, on the interface, and prove that X^L(t, s) converges to the Brownian sheet as L for sufficiently large, whereL denotes the size of the system. This result does not mean that the interface itself converges to the Brownian sheet.     

Analytical procedures for quantification of peptides in pharmaceutical research by liquid chromatography–mass spectrometry

Peptide quantification by liquid chromatography–mass spectrometry (LC–MS) combines the high resolving power of reversed-phase (RP) chromatography with the excellent selectivity and sensitivity of mass spectrometric detection. On the basis of comprehensive practical experience in the analysis of small molecules, pharmaceutical research is developing technologies for analysis of a growing number of peptidic drug candidates. This article is a detailed review of procedures based on LC–MS techniques for quantitative determination of peptides. With the focus on pharmaceutical applications several technologies for sample preparation, various aspects of peptide chromatography, important characteristics of ESI–MS, selectivity of MS-detection modes, the large variability of internal standards, and modern instrumentation are discussed. The demand for reliable, robust, sensitive, and accurate methods is discussed using numerous examples from the literature, complemented by experiments and results from our laboratory.     

气相色谱叠加定量方法的研究

叠加法是由内标法衍生而来的一种气相色谱定量方法。对于较复杂混合物的分析,当选择内标物困难时,用叠加法定量更为方便。本文在大量实验的基础上,提出了叠加法定量过程中应注意的一些问题。     

Estimation of the size of liposomes by modified HDC

Internal calibration in modified hydrodynamic chromatography has been realized by the approach of Prieve and Hoysan, i.e. the use of polystyrene monodisperse latexes to evaluate the equivalent capillary radius, R. The value obtained has been used to estimate the average sizes of a variety of liposome samples from egg yolk lecithin.     

Selecting parameters and limits for equipment operational qualification

While operational qualification (OQ) is a well-established term within equipment qualification, users of equipment often become unsure when it comes to implementation. The biggest problem is how to select procedures and acceptance criteria. Should these be the vendor's specifications or should the users define their own limits, and, if so, how? Should all instruments of the same type have the same values or should these be optimized for each individual instrument? This article will provide an overall strategy and specific examples for HPLC on how to select procedures and acceptance limits that are based on efficient use of resources, on practicality and on the intended use of the equipment.     

非均相羰基氧化合成碳酸二苯酯反应液组分的分析

通过色质联用仪对非均相催化一步合成碳酸二苯酯(DPC)过程中的反应液的主要产物及副产物进行了定性分析，其结果发现该反应的主要副产物为苯氧基丙酸和4-苯氧基苯酚以及四丁基铵盐；用气相色谱外标法对反应液中的DPC进行了定量分析，并通过回归法得到了定量分析：DPC的计算方程式，实验证明该方程在DPC的浓度小于10％范围内比较可靠。     

最小一乘稳健多元分析校正

本文论述最小一乘求解的多元分析校正算法，探讨了最小一乘较常规最小二乘法及其他隐健算法的优点。用计算机数值模拟及实际多组分光谱体系对方法进行了检验，展示了最小一乘法在分析化学计量学中实际应用的可行性。